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AML Venetoclax Treatment Regimen: Understanding Dosage

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Published on July 26, 2019

How do doctors balance treatment efficacy and toxicity for acute myeloid leukemia (AML) patients on venetoclax (Venclexta)? During this Ask the Expert segment, Dr. Daniel Pollyea, from the University of Colorado School of Medicine, explains the standard recommended dosage and when dose reduction is appropriate.  

This program is sponsored by AbbVie, Inc and Genentech, Inc. It is produced by Patient Power in partnership with The Leukemia & Lymphoma Society (LLS) and NeedyMeds. These organizations have no editorial control, and Patient Power is solely responsible for program content.

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Transcript | AML Venetoclax Treatment Regimen: Understanding Dosage

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That's how you’ll get care that's most appropriate for you.

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you.

Andrew Schorr:          

We got a question, and people were asking, well, is there a venetoclax (Venclexta) dose that is too low? So, how do you figure out the right dose so that it’s effective and side effects are non-significant?

Dr. Pollyea:                 

Sure. Well, the FDA approval is for 400 milligrams of venetoclax. So, venetoclax comes in 100 milligram tablets, so four of those a day. There's scale up to get to that dose the first couple days of the first cycle we like to escalate up to 400 milligrams slowly for a variety of reasons. So, that is the standard accepted dose for venetoclax. There are some opportunities to reduce the doses of venetoclax depending on the situation. 

Sometimes, if a patient needs to be on a certain class of medications that can interact with the venetoclax, we have to reduce the dose. Sometimes, if a person's blood counts are low and the treating physical believes that they are low because of the venetoclax, it may be appropriate to reduce the dose. But the standard dose of venetoclax after that initial scale up is four pills or 400 milligrams a day.

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you.