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Are There Any Maintenance Therapies Currently in Development?

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Published on June 16, 2015

Transcript | Are There Any Maintenance Therapies Currently in Development?

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you. 

Andrew Schorr:

Here’s a question we got in from Blair. Blair wants to know, “Are any other drugs in development or trials for use specifically in maintenance therapy?”

Dr. Morgan:

So the kind of important thing about maintenance is it does seem to be important. And when you look at the impact of maintenance, it really does seem to be pushing out disease-free periods and increasing the number of people kind of are cured.  So I see a big impact of maintenance. 

We've been using bortezomib (VELCADE®) and lenalidomide (REVLIMID®) together, so a combination of a proteasome inhibitor and an IMiD drug.  We have really good results with that.  I guess your question is what can you put into that backbone to improve outcomes?  And so for me, I think there's a real place for using the antibodies.  In maintenance, it's really important you don't have side effects, that you don't get infections or have things that take away from the patient's quality of life.  And so I think there's going to be a big, big role for anti-CD38 treatment, moving away from intravenous treatments or subcutaneous injections to oral medications. 

So the advent of ixazomib as an oral proteasome inhibitor that a patient can take close to their home is going to be a big step forward.  So, you know, watch this space for improving outcomes by using maintenance.  But above all, you should not get side effects, and your quality of life should be good.  

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you. 

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