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Kate Buck was diagnosed with essential thrombocythemia (ET) back in 2004 at the age of 50. Kate had been searching for a diagnosis for 7 years after dealing with issues with her legs and feet—pain, difficultly walking, changes in color and hot/cold. She had seen podiatrists, cardiologists and even a hematologist who overlooked the high platelet count. After finally being diagnosed, she started on treatment and was doing well for some time being seen by a new hematologist regularly. After many years on the same treatment, Kate switched treatments and ended up in the hospital with some potentially unrelated issues—her platelets were in range so she suggested giving her body a break from treatment and her doctor agreed. The next year, she moved to California and, shortly thereafter, she was feeling dehydrated and a 7-milimeter blood clot was discovered, even though her numbers were in range. Kate was put back on treatment for her MPN along with a blood thinner. She sees Dr. Gotlib every 3 to 4 months and feels great, with no MPN symptoms. Kate is married with four children and enjoys outdoor sports such as kayaking, water aerobics, traveling, reading and baking.