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Margie was diagnosed with essential thrombocythemia (ET) in 2002 after experiencing persistent nose bleeds and fatigue. At the time, she was working as a research nurse and has maintained a positive attitude about her condition. Her initial therapy was hydroxyurea. Over the years, her ET progressed to polycythemia vera (PV) and later to myelofibrosis (MF). Margie is followed closely by Dr. Snyder at City of Hope and is now participating in a clinical trial. She is now retired and has children and grandchildren. In her spare time, Margie enjoys volunteering—spending 3 months per year working with children and adults in Thailand.