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Can Myeloma Patients Stop Treatment After Transplant?

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Published on August 22, 2018

What’s next for multiple myeloma patients after a transplant? Can treatment be stopped altogether if patients have a good response? Myeloma expert Dr. Amrita Krishnan, from City of Hope, discusses the recommendations for post-transplant care and maintenance therapy based on clinical trial data gathered in Europe and the United States. Watch now to find out more.

This is a Patient Empowerment Network program produced by Patient Power. We thank AbbVie, Inc., Celgene Corporation, and Takeda Oncology for their support.

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Transcript | Can Myeloma Patients Stop Treatment After Transplant?

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That's how you’ll get care that's most appropriate for you.

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you.

Jack Aiello:

In the autologous setting we have differences right now.  We do have…

The French had a trial that actually started out with the same idea, indefinite lenalidomide.  They ended up abrogating it because of their concerns for toxicity.  The patients in that study had about 18 months of lenalidomide.  

And then lastly there's a big trial that's going on right now that the IFM Dana-Farber trial that in this French part patient after transplant might get lenalidomide only for a year.  The U.S. part patients get lenalidomide indefinitely, so it tells you that, you know, we can't really—don't know and we can't agree.  

The last point I would say is a trial, which you're very familiar with, Jack—you've been hugely instrumental in getting it off the ground, is trying to answer that very question, which is transplant get randomized to lenalidomide or lenalidomide and daratumumab (Darzalex), and then after two years if they're MRD negative, so really looking very, very deeply at their myeloma, patients will have a second randomization, so a group of patients both stop therapy, so that will answer the question can you stop therapy if you've had a very, very good response.  

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you.